The correlation between relatives on the supposition of genomic imprinting.

O-11: N-a-acetyltransferase 10 Protein Regulates DNA Methylation and Embryonic Development

Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...

اهمیت خویشاوندی ژنتیکی و رکورد فنوتیپی بر صحت ژنومی داده‌های جانهی شبیه‌ سازی شده با استفاده از مدل های حیوانی در حضور اثرات متقابل ژنوتیپ و محیط

The objective of this study was to investigate the role of genetic relationships between training and validation set with considering different ratio of phenotypic records of training set on accuracy of genomic prediction via animal models containing genotype × environment interactions in simulated imputation data. For this purpose, four different scenarios using 15k density containing differen...

Influence of mom and dad: quantitative genetic models for maternal effects and genomic imprinting.

The expression of an imprinted gene is dependent on the sex of the parent it was inherited from, and as a result reciprocal heterozygotes may display different phenotypes. In contrast, maternal genetic terms arise when the phenotype of an offspring is influenced by the phenotype of its mother beyond the direct inheritance of alleles. Both maternal effects and imprinting may contribute to resemb...

A note on the background to, and refereeing of, R. A. Fisher's 1918 paper 'On the correlation between relatives on the supposition of Mendelian inheritance'.

Comparative study of chemo-sensitivity expressed as micronuclei in lymphocytes of breast cancer patients, their unaffected first degree relatives and normal controls as a possible prognostic marker

Background: Genomic instability is one of primary causes for malignant cell transformation. In this study induced genomic instability expressed as micronuclei in breast cancer (BC) patients with different stages of the disease compared with their unaffected first degree relatives (FDR) and normal unrelated controls was investigated. Materials and Methods: The background and net micronucleus fre...